4IA0
Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors
Summary for 4IA0
Entry DOI | 10.2210/pdb4ia0/pdb |
Related | 4I9Z |
Descriptor | cGMP-specific 3',5'-cyclic phosphodiesterase, 5-bromo-2-{2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-6-octylpyrimidin-4(3H)-one, ZINC ION, ... (5 entities in total) |
Functional Keywords | hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens |
Total number of polymer chains | 1 |
Total formula weight | 40750.36 |
Authors | |
Primary citation | Gong, X.,Wang, G.,Ren, J.,Liu, Z.,Wang, Z.,Chen, T.,Yang, X.,Jiang, X.,Shen, J.,Jiang, H.,Aisa, H.A.,Xu, Y.,Li, J. Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5. Bioorg.Med.Chem.Lett., 23:4944-4947, 2013 Cited by PubMed: 23867165DOI: 10.1016/j.bmcl.2013.06.062 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.17 Å) |
Structure validation
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