4HYF
Structural basis and SAR for OD 270, a lead stage 1,2,4-triazole based specific Tankyrase1/2 inhibitor
Summary for 4HYF
Entry DOI | 10.2210/pdb4hyf/pdb |
Related | 3KR7 3KR8 3P0N 3U9Y 4HKI 4HKN |
Descriptor | Tankyrase-2, NICOTINAMIDE, ZINC ION, ... (5 entities in total) |
Functional Keywords | catalytic fragment, parp, adp-ribosylation, ank repeat, chromosomal protein, glycosyltransferase, phosphorylation, telomere, transferase, translocation, transport, wnt-signalling, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q9H2K2 |
Total number of polymer chains | 3 |
Total formula weight | 84051.77 |
Authors | Perdreau, H.,Ekblad, B.,Voronkov, A.,Holsworth, D.D.,Waaler, J.,Drewes, G.,Schueler, H.,Krauss, S.,Morth, J.P. (deposition date: 2012-11-13, release date: 2013-03-20, Last modification date: 2023-09-20) |
Primary citation | Voronkov, A.,Holsworth, D.D.,Waaler, J.,Wilson, S.R.,Ekblad, B.,Perdreau-Dahl, H.,Dinh, H.,Drewes, G.,Hopf, C.,Morth, J.P.,Krauss, S. Structural Basis and SAR for G007-LK, a Lead Stage 1,2,4-Triazole Based Specific Tankyrase 1/2 Inhibitor. J.Med.Chem., 56:3012-3023, 2013 Cited by PubMed: 23473363DOI: 10.1021/jm4000566 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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