4FZJ

Pantothenate synthetase in complex with 1,3-DIMETHYL-1H-THIENO[2,3-C]PYRAZOLE-5-CARBOXYLIC ACID

Summary for 4FZJ

Entry DOI	10.2210/pdb4fzj/pdb
Related	4DDH 4DDK 4DDM 4DE5 4EF6 4EFK
Descriptor	Pantothenate synthetase, ETHANOL, 1,2-ETHANEDIOL, ... (6 entities in total)
Functional Keywords	rossmann fold, atp + (r)-pantoate + beta-alanine, citoplasm, ligase
Biological source	Mycobacterium tuberculosis
Cellular location	Cytoplasm (Potential): P0A5R0
Total number of polymer chains	2
Total formula weight	64672.17
Authors	Silvestre, H.L.,Blundell, T.L.,Abell, C.,Ciulli, A. (deposition date: 2012-07-06, release date: 2013-06-26, Last modification date: 2024-02-28)
Primary citation	Silvestre, H.L.,Blundell, T.L.,Abell, C.,Ciulli, A. Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery. Proc.Natl.Acad.Sci.USA, 110:12984-12989, 2013 Cited by PubMed: 23872845 DOI: 10.1073/pnas.1304045110 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.63 Å)

Structure validation