4FDH
Structure of human aldosterone synthase, CYP11B2, in complex with fadrozole
Summary for 4FDH
Entry DOI | 10.2210/pdb4fdh/pdb |
Related | 4DVQ |
Descriptor | Cytochrome P450 11B2, mitochondrial, PROTOPORPHYRIN IX CONTAINING FE, 4-[(5R)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl]benzonitrile, ... (4 entities in total) |
Functional Keywords | cytochrome p450, cyp11b2, aldosterone synthase, monooxygenase, heme protein, mineralocorticoid, inhibitor, mitochondria, membrane, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Mitochondrion membrane: P19099 |
Total number of polymer chains | 12 |
Total formula weight | 677871.12 |
Authors | Strushkevich, N.,Shen, L.,Tempel, W.,Arrowsmith, C.,Edwards, A.,Usanov, S.A.,Park, H.-W. (deposition date: 2012-05-28, release date: 2013-01-30, Last modification date: 2024-02-28) |
Primary citation | Strushkevich, N.,Gilep, A.A.,Shen, L.,Arrowsmith, C.H.,Edwards, A.M.,Usanov, S.A.,Park, H.W. Structural insights into aldosterone synthase substrate specificity and targeted inhibition. Mol.Endocrinol., 27:315-324, 2013 Cited by PubMed: 23322723DOI: 10.1210/me.2012-1287 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.71 Å) |
Structure validation
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