4F70

Crystal structure of human CDK8/CYCC in complex with compound 4 (1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-[2-(morpholin-4-yl)ethyl]urea)

Summary for 4F70

Entry DOI	10.2210/pdb4f70/pdb
Related	4F6S 4F6U 4F6W 4F7J 4F7L 4F7N
Descriptor	Cyclin-dependent kinase 8, Cyclin-C, 1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-[2-(morpholin-4-yl)ethyl]urea, ... (5 entities in total)
Functional Keywords	protein kinase complex, proteros, transferase-transcription-inhibitor complex, transferase/transcription/inhibitor
Biological source	Homo sapiens (human) More
Cellular location	Nucleus : P49336 P24863
Total number of polymer chains	2
Total formula weight	81148.50
Authors	Schneider, E.V.,Boettcher, J.,Huber, R.,Maskos, K. (deposition date: 2012-05-15, release date: 2013-05-01, Last modification date: 2023-09-13)
Primary citation	Schneider, E.V.,Bottcher, J.,Huber, R.,Maskos, K.,Neumann, L. Structure-kinetic relationship study of CDK8/CycC specific compounds. Proc.Natl.Acad.Sci.USA, 110:8081-8086, 2013 Cited by PubMed: 23630251 DOI: 10.1073/pnas.1305378110 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation