4F3I
Crystal structure of the first bromodomain of human BRD4 in complex with MS417 inhibitor
Summary for 4F3I
Entry DOI | 10.2210/pdb4f3i/pdb |
Descriptor | Bromodomain-containing protein 4, 1,2-ETHANEDIOL, methyl [(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate, ... (4 entities in total) |
Functional Keywords | protein-inhibitor complex, acetyl-lysine binding, nucleus, signaling protein-inhibitor complex, signaling protein/inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: O60885 |
Total number of polymer chains | 1 |
Total formula weight | 15638.42 |
Authors | Joshua, J.,Zhou, M.-M.,Plotnikov, A.N. (deposition date: 2012-05-09, release date: 2012-09-12, Last modification date: 2023-09-13) |
Primary citation | Zhang, G.,Liu, R.,Zhong, Y.,Plotnikov, A.N.,Zhang, W.,Zeng, L.,Rusinova, E.,Gerona-Nevarro, G.,Moshkina, N.,Joshua, J.,Chuang, P.Y.,Ohlmeyer, M.,He, J.C.,Zhou, M.M. Down-regulation of NF-{kappa}B Transcriptional Activity in HIV-associated Kidney Disease by BRD4 Inhibition. J.Biol.Chem., 287:28840-28851, 2012 Cited by PubMed: 22645123DOI: 10.1074/jbc.M112.359505 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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