4EFM

Crystal structure of H-Ras G12V in complex with GppNHp (state 1)

Summary for 4EFM

Entry DOI	10.2210/pdb4efm/pdb
Related	1XCM 3KKN 4EFL 4EFN
Descriptor	GTPase HRas, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	rossmann fold, gtpase, gtp-binding, signaling protein
Biological source	Homo sapiens (human)
Cellular location	Cell membrane. Isoform 2: Nucleus: P01112
Total number of polymer chains	1
Total formula weight	19875.23
Authors	Muraoka, S.,Shima, F.,Araki, M.,Inoue, T.,Yoshimoto, A.,Ijiri, Y.,Seki, N.,Tamura, A.,Kumasaka, T.,Yamamoto, M.,Kataoka, T. (deposition date: 2012-03-30, release date: 2012-05-16, Last modification date: 2023-11-08)
Primary citation	Muraoka, S.,Shima, F.,Araki, M.,Inoue, T.,Yoshimoto, A.,Ijiri, Y.,Seki, N.,Tamura, A.,Kumasaka, T.,Yamamoto, M.,Kataoka, T. Crystal structures of the state 1 conformations of the GTP-bound H-Ras protein and its oncogenic G12V and Q61L mutants Febs Lett., 586:1715-1718, 2012 Cited by PubMed: 22584058 DOI: 10.1016/j.febslet.2012.04.058 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation