4E5X

Crystal structure of a complex between the human adenovirus type 2 E3-19K protein and MHC class I molecule HLA-A2/Tax

Summary for 4E5X

Entry DOI	10.2210/pdb4e5x/pdb
Descriptor	HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, Protein Tax-1, ... (5 entities in total)
Functional Keywords	ad2 e3-19k-hla-a2 complex, unique tertiary structure, adenovirus e3-19k, immune evasion function, mhc class i molecule, endoplasmic reticulum, immune system-transcription complex, immune system/transcription
Biological source	Homo sapiens (human) More
Cellular location	Membrane; Single-pass type I membrane protein: P01892 Secreted: P61769 Host nucleus (By similarity): P0C213 Host endoplasmic reticulum membrane; Single- pass type I membrane protein: P68979
Total number of polymer chains	8
Total formula weight	113485.32
Authors	Li, L.,Bouvier, M. (deposition date: 2012-03-14, release date: 2012-10-10, Last modification date: 2023-09-13)
Primary citation	Li, L.,Muzahim, Y.,Bouvier, M. Crystal structure of adenovirus E3-19K bound to HLA-A2 reveals mechanism for immunomodulation. Nat.Struct.Mol.Biol., 19:1176-1181, 2012 Cited by PubMed: 23042604 DOI: 10.1038/nsmb.2396 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation