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4DG6

Crystal structure of domains 1 and 2 of LRP6

Summary for 4DG6
Entry DOI10.2210/pdb4dg6/pdb
DescriptorLow-density lipoprotein receptor-related protein 6, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PHOSPHATE ION, ... (4 entities in total)
Functional Keywords6-bladed beta propeller, sclerostin receptor, egf, wnt, mesd, signaling protein
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight71071.71
Authors
Ceska, T.A.,Doyle, C.,Slocombe, P. (deposition date: 2012-01-25, release date: 2012-06-13, Last modification date: 2024-11-20)
Primary citationHoldsworth, G.,Slocombe, P.,Doyle, C.,Sweeney, B.,Veverka, V.,Le Rich, K.,Franklin, R.J.,Brookings, D.,Turner, J.,Kennedy, J.,Garlish, R.,Shi, J.,Newnham, L.,McMillan, D.,Muzylak, M.,Carr, M.,Henry, A.J.,Ceska, T.,Robinson, M.K.
Characterization of the interaction of sclerostin with the LRP family of Wnt co-receptors
To be Published,
Experimental method
X-RAY DIFFRACTION (2.9 Å)
Structure validation

227561

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