4D9T
Rsk2 C-terminal Kinase Domain with inhibitor (E)-methyl 3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyanoacrylate
Summary for 4D9T
Entry DOI | 10.2210/pdb4d9t/pdb |
Related | 4D9U |
Descriptor | Ribosomal protein S6 kinase alpha-3, methyl (2S)-3-{4-amino-7-[(1E)-3-hydroxyprop-1-en-1-yl]-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl}-2-cyanopropanoate, SODIUM ION, ... (4 entities in total) |
Functional Keywords | kinase, inhibitor, reversible, thiol, phosphorylation, migration, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus (By similarity): P51812 |
Total number of polymer chains | 1 |
Total formula weight | 38893.34 |
Authors | Serafimova, I.M.,Pufall, M.A.,Krishnan, S.,Duda, K.,Cohen, M.S.,Maglathlin, R.L.,McFarland, J.M.,Miller, R.M.,Frodin, M.,Taunton, J. (deposition date: 2012-01-12, release date: 2012-04-25, Last modification date: 2012-05-16) |
Primary citation | Serafimova, I.M.,Pufall, M.A.,Krishnan, S.,Duda, K.,Cohen, M.S.,Maglathlin, R.L.,McFarland, J.M.,Miller, R.M.,Frodin, M.,Taunton, J. Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles. Nat.Chem.Biol., 8:471-476, 2012 Cited by PubMed: 22466421DOI: 10.1038/nchembio.925 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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