4D71
Crystal structure of a family 98 glycoside hydrolase catalytic module (Sp3GH98) in complex with the type 2 blood group A-tetrasaccharide (E558A X02 mutant)
Summary for 4D71
Entry DOI | 10.2210/pdb4d71/pdb |
Related | 4D72 |
Descriptor | GLYCOSIDE HYDROLASE, alpha-L-fucopyranose-(1-2)-[2-acetamido-2-deoxy-alpha-D-galactopyranose-(1-3)]beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | hydrolase, blood group antigen |
Biological source | STREPTOCOCCUS PNEUMONIAE |
Total number of polymer chains | 1 |
Total formula weight | 69885.18 |
Authors | Kwan, D.H.,Constantinescu, I.,Chapanian, R.,Higgins, M.A.,Samain, E.,Boraston, A.B.,Kizhakkedathu, J.N.,Withers, S.G. (deposition date: 2014-11-19, release date: 2015-01-21, Last modification date: 2023-12-20) |
Primary citation | Kwan, D.H.,Constantinescu, I.,Chapanian, R.,Higgins, M.A.,Koetzler, M.,Samain, E.,Boraston, A.B.,Kizhakkedathu, J.N.,Withers, S.G. Towards Efficient Enzymes for the Generation of Universal Blood Through Structure-Guided Directed Evolution. J.Am.Chem.Soc., 137:5695-, 2015 Cited by PubMed: 25870881DOI: 10.1021/JA5116088 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.77 Å) |
Structure validation
Download full validation report