4CWQ
Human HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor
Summary for 4CWQ
Entry DOI | 10.2210/pdb4cwq/pdb |
Related | 4CWF 4CWN 4CWO 4CWP 4CWR 4CWS 4CWT |
Descriptor | HEAT SHOCK PROTEIN HSP 90-ALPHA, 2-amino-5-(1,3-benzodioxol-5-ylmethyl)[1,2,4]triazolo[1,5-c]quinazoline-8-sulfonamide (3 entities in total) |
Functional Keywords | chaperone |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cytoplasm : P07900 |
Total number of polymer chains | 1 |
Total formula weight | 26209.33 |
Authors | Casale, E.,Amboldi, N.,Brasca, G.,Caronni, D.,Colombo, N.,Dalvit, C.,Felder, E.R.,Fogliatto, G.,Isacchi, A.,Mantegani, S.,Polucci, P.,Riceputi, L.,Sola, F.,Visco, C.,Zuccotto, F.,Casuscelli, F. (deposition date: 2014-04-03, release date: 2014-07-09, Last modification date: 2024-05-08) |
Primary citation | Casale, E.,Amboldi, N.,Brasca, M.G.,Caronni, D.,Colombo, N.,Dalvit, C.,Felder, E.R.,Fogliatto, G.,Galvani, A.,Isacchi, A.,Polucci, P.,Riceputi, L.,Sola, F.,Visco, C.,Zuccotto, F.,Casuscelli, F. Fragment-Based Hit Discovery and Structure-Based Optimization of Aminotriazoloquinazolines as Novel Hsp90 Inhibitors. Bioorg.Med.Chem., 22:4135-, 2014 Cited by PubMed: 24980703DOI: 10.1016/J.BMC.2014.05.056 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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