4CM5
Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor and inhibitor
Summary for 4CM5
Entry DOI | 10.2210/pdb4cm5/pdb |
Related | 4CL8 4CLD 4CLE 4CLH 4CLO 4CLR 4CLX 4CM1 4CM3 4CM4 4CM6 4CM7 4CM8 4CM9 4CMA 4CMB 4CMC 4CME 4CMG 4CMI 4CMJ 4CMK |
Descriptor | PTERIDINE REDUCTASE 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-amino-6-(3-formylphenyl)-4-(pyrrolidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, ... (4 entities in total) |
Functional Keywords | oxidoreductase, ptr1, short-chain dehydrogenase/reductase |
Biological source | TRYPANOSOMA BRUCEI BRUCEI |
Total number of polymer chains | 4 |
Total formula weight | 126982.22 |
Authors | Barrack, K.L.,Hunter, W.N. (deposition date: 2014-01-15, release date: 2015-01-21, Last modification date: 2023-12-20) |
Primary citation | Khalaf, A.I.,Huggan, J.K.,Suckling, C.J.,Gibson, C.L.,Stewart, K.,Giordani, F.,Barrett, M.P.,Wong, P.E.,Barrack, K.L.,Hunter, W.N. Structure-Based Design and Synthesis of Antiparasitic Pyrrolopyrimidines Targeting Pteridine Reductase 1. J.Med.Chem., 57:6479-, 2014 Cited by PubMed: 25007262DOI: 10.1021/JM500483B PDB entries with the same primary citation |
Experimental method |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)