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4C5D

Crystal structure of Bcl-xL in complex with benzoylurea compound (42)

Summary for 4C5D
Entry DOI10.2210/pdb4c5d/pdb
Related4C52
DescriptorBCL-2-LIKE PROTEIN 1, (R)-3-(4-BROMOBENZYLTHIO)-2-(3-(3-((2,4-DIFLUOROPHENYL)ETHYNYL)BENZOYL)-3-PROPYLUREIDO)PROPANOIC ACID, SULFATE ION, ... (5 entities in total)
Functional Keywordsapoptosis, bcl-2
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationIsoform Bcl-X(L): Mitochondrion inner membrane (By similarity): Q07817
Total number of polymer chains2
Total formula weight38263.95
Authors
Roy, M.J.,Brady, R.M.,Lessene, G.,Colman, P.M.,Czabotar, P.E. (deposition date: 2013-09-11, release date: 2014-02-05, Last modification date: 2023-12-20)
Primary citationBrady, R.M.,Vom, A.,Roy, M.J.,Toovey, N.,Smith, B.J.,Moss, R.M.,Hazis, E.,Huang, D.C.S.,Parisot, J.P.,Yang, H.,Street, I.P.,Colman, P.M.,Czabotar, P.E.,Baell, J.B.,Lessene, G.
De-Novo Designed Library of Benzoylureas as Inhibitors of Bcl-Xl: Synthesis, Structural and Biochemical Characterization.
J.Med.Chem., 57:1323-, 2014
Cited by
PubMed: 24456288
DOI: 10.1021/JM401948B
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation

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