4BNI
Crystal structure of S. aureus FabI in complex with NADP and 2-(2- aminophenoxy)-5-hexylphenol
Summary for 4BNI
Entry DOI | 10.2210/pdb4bni/pdb |
Related | 4BNF 4BNG 4BNH 4BNJ 4BNK 4BNL 4BNM 4BNN |
Descriptor | ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADPH], GLUTAMIC ACID, 2-(2-azanylphenoxy)-5-hexyl-phenol, ... (5 entities in total) |
Functional Keywords | short-chain dehydrogenase/reductase superfamily, fatty acid biosynthesis, lipid synthesis, safabi, oxidoreductase |
Biological source | STAPHYLOCOCCUS AUREUS SUBSP. AUREUS |
Total number of polymer chains | 8 |
Total formula weight | 258414.11 |
Authors | Schiebel, J.,Chang, A.,Bommineni, G.R.,Tonge, P.J.,Kisker, C. (deposition date: 2013-05-15, release date: 2013-06-05, Last modification date: 2023-12-20) |
Primary citation | Chang, A.,Schiebel, J.,Yu, W.,Bommineni, G.R.,Pan, P.,Baxter, M.V.,Khanna, A.,Sotriffer, C.A.,Kisker, C.F.,Tonge, P.J. Rational Optimization of Drug-Target Residence Time: Insights from Inhibitor Binding to the S. Aureus Fabi Enzyme-Product Complex. Biochemistry, 52:4217-, 2013 Cited by PubMed: 23697754DOI: 10.1021/BI400413C PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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