4BBX
Discovery of a potent, selective and orally active PDE10A inhibitor for the treatment of schizophrenia
Summary for 4BBX
Entry DOI | 10.2210/pdb4bbx/pdb |
Related | 1LRB 2WEY 2Y0J 4AEL 4AJD 4AJF 4AJG 4AJM |
Descriptor | CAMP AND CAMP-INHIBITED CGMP 3', 5'-CYCLIC PHOSPHODIESTERASE 10A, 4-[3-[1-[(2S)-2-methoxypropyl]pyrazol-4-yl]-2-methyl-imidazo[1,2-a]pyrazin-8-yl]morpholine, ZINC ION, ... (5 entities in total) |
Functional Keywords | phosphodiesterase inhibitor, inhibitor complex, hydrolase, zinc binding, magnesium binding |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cytoplasm: Q9Y233 |
Total number of polymer chains | 2 |
Total formula weight | 78873.80 |
Authors | Bartolome-Nebreda, J.M.,Conde-Ceide, S.,Delgado, F.,Martin, M.L.,Martinez-Viturro, C.M.,Pastor, J.,Tong, H.M.,Iturrino, L.,Macdonald, G.J.,Sanderson, W.,Megens, A.,Langlois, X.,Somers, M.,Vanhoof, G. (deposition date: 2012-09-28, release date: 2013-10-16, Last modification date: 2024-05-08) |
Primary citation | Bartolome-Nebreda, J.M.,Delgado, F.,Martin, M.L.,Martinez-Viturro, C.M.,Pastor, J.,Tong, H.M.,Iturrino, L.,Macdonald, G.J.,Sanderson, W.E.,Megens, A.,Langlois, X.,Somers, M.,Vanhoof, G.,Conde Ceide, S. Discovery of a Potent, Selective and Orally Active Pde10A Inhibitor for the Potential Treatment of Schizophrenia. J.Med.Chem., 57:4196-, 2014 Cited by PubMed: 24758746DOI: 10.1021/JM500073H PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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