4AV0

Structure of the FimH lectin domain in the trigonal space group, in complex with a methoxy phenyl propynyl alpha-D-mannoside at 2.1 A resolution

Summary for 4AV0

• Entry DOI: 10.2210/pdb4av0/pdb
• Related: 4ATT 4AUJ 4AUU 4AUY
• Descriptor: FIMH, 3-(4-methoxyphenyl)prop-2-yn-1-yl alpha-D-mannopyranoside, NICKEL (II) ION, ... (5 entities in total)
• Functional Keywords: cell adhesion, bacterial adhesin, type 1 fimbriae, urinary tract infection, variable immunoglobulin fold
• Biological source: ESCHERICHIA COLI
• Total number of polymer chains: 2
• Total formula weight: 34695.76

Authors

Wellens, A.,Lahmann, M.,Touaibia, M.,Vaucher, J.,Oscarson, S.,Roy, R.,Remaut, H.,Bouckaert, J. (deposition date: 2012-05-23, release date: 2012-06-27, Last modification date: 2023-12-20)

• Primary citation: Wellens, A.,Lahmann, M.,Touaibia, M.,Vaucher, J.,Oscarson, S.,Roy, R.,Remaut, H.,Bouckaert, J.; The Tyrosine Gate as a Potential Entropic Lever in the Receptor-Binding Site of the Bacterial Adhesin Fimh.; Biochemistry, 51:4790-, 2012; PubMed: 22657089; DOI: 10.1021/BI300251R

Experimental method

X-RAY DIFFRACTION (2.099 Å)