4ALV
Benzofuropyrimidinone Inhibitors of Pim-1
Summary for 4ALV
Entry DOI | 10.2210/pdb4alv/pdb |
Related | 1XQZ 1XR1 1XWS 1YHS 1YI3 1YI4 1YWV 1YXS 1YXT 1YXU 1YXV 1YXX 2BIK 2BIL 2BZH 2BZI 2BZJ 2BZK 2C3I 2J2I 2XIX 2XIY 2XIZ 2XJ0 2XJ1 2XJ2 4A7C 4ALU 4ALW |
Descriptor | SERINE/THREONINE-PROTEIN KINASE PIM-1, IMIDAZOLE, 8-bromo-2-{2-chloro-4-[(piperidin-4-ylmethyl)amino]phenyl}[1]benzofuro[3,2-d]pyrimidin-4(3H)-one, ... (4 entities in total) |
Functional Keywords | proto-oncogene, transferase |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309 |
Total number of polymer chains | 1 |
Total formula weight | 38114.51 |
Authors | Stout, T.J.,Adams, L. (deposition date: 2012-03-05, release date: 2013-01-16, Last modification date: 2024-05-01) |
Primary citation | Tsuhako, A.L.,Brown, D.S.,Koltun, E.S.,Aay, N.,Arcalas, A.,Chan, V.,Du, H.,Engst, S.,Franzini, M.,Galan, A.,Huang, P.,Johnston, S.,Kane, B.,Kim, M.H.,Laird, A.D.,Lin, R.,Mock, L.,Ngan, I.,Pack, M.,Stott, G.,Stout, T.J.,Yu, P.,Zaharia, C.,Zhang, W.,Zhou, P.,Nuss, J.M.,Kearney, P.C.,Xu, W. The Design, Synthesis, and Biological Evaluation of Pim Kinase Inhibitors. Bioorg.Med.Chem.Lett., 22:3732-, 2012 Cited by PubMed: 22542012DOI: 10.1016/J.BMCL.2012.04.025 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.59 Å) |
Structure validation
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