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4AJI

rat LDHA in complex with 2-((3,4-dimethoxyphenyl)methyl))propanedioic acid

Summary for 4AJI
Entry DOI10.2210/pdb4aji/pdb
Related4AJ1 4AJ2 4AJ4 4AJE 4AJH 4AJJ 4AJK 4AJL 4AJN 4AJO
DescriptorL-LACTATE DEHYDROGENASE A CHAIN, 2-((3,4-DIMETHOXYPHENYL)METHYL))PROPANEDIOIC ACID (3 entities in total)
Functional Keywordsoxidoreductase-inhibitor complex, fragment based lead generated inhibitors, oxidoreductase/inhibitor
Biological sourceRATTUS NORVEGICUS (NORWAY RAT)
Cellular locationCytoplasm: P04642
Total number of polymer chains4
Total formula weight146469.90
Authors
Tucker, J.A.,Brassington, C.,Hassall, G.,Vogtherr, M.,Ward, R.,Tart, J.,Davies, G.,Debreczeni, J. (deposition date: 2012-02-16, release date: 2012-03-21, Last modification date: 2018-04-04)
Primary citationWard, R.,Brassington, C.,Breeze, A.L.,Caputo, A.,Critchlow, S.,Davies, G.,Goodwin, L.,Hassall, G.,Greenwood, R.,Holdgate, G.,Mrosek, M.,Norman, R.A.,Pearson, S.,Tart, J.,Tucker, J.A.,Vogtherr, M.,Whittaker, D.,Wingfield, J.,Winter, J.,Hudson, K.
The Design and Synthesis of Novel Lactate Dehydrogenase a Inhibitors by Fragment-Based Lead Generation
J.Med.Chem., 55:3285-, 2012
Cited by
PubMed: 22417091
DOI: 10.1021/JM201734R
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.93 Å)
Structure validation

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