6TAV

Crystal structure of endopeptidase-induced alpha2-macroglobulin

Replaces:  4ACQ

Summary for 6TAV

• Entry DOI: 10.2210/pdb6tav/pdb
• Descriptor: Alpha-2-macroglobulin, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: peptidase inhibitor, proteinase inhibitor, zn-and cu-binding protein, cytokine binding, hormone binding, protein binding, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 666202.72

Authors

Gomis-Ruth, F.X.,Duquerroy, S.,Trapani, S.,Marrero, A.,Goulas, T.,Guevara, T.,Andersen, G.A.,Sottrup-Jensen, L.,Navaza, J. (deposition date: 2019-10-30, release date: 2021-05-12, Last modification date: 2024-01-24)

• Primary citation: Luque, D.,Goulas, T.,Mata, C.P.,Mendes, S.R.,Gomis-Ruth, F.X.,Caston, J.R.; Cryo-EM structures shows the mechanistic basis of pan-peptidase inhibition by human alpha2-macroglobulin; Proc.Natl.Acad.Sci.USA, 2022

Experimental method

X-RAY DIFFRACTION (4.2 Å)