465D

STRUCTURE OF THE TOPOISOMERASE II POISON BOUND TO DNA

Summary for 465D

• Entry DOI: 10.2210/pdb465d/pdb
• Descriptor: DNA (5'-D(*CP*GP*TP*AP*CP*G)-3'), 9-AMINO-(N-(2-DIMETHYLAMINO)ETHYL)ACRIDINE-4-CARBOXAMIDE (3 entities in total)
• Functional Keywords: topoisomerase ii poison, hexanucleotide, d(cgtacg)2, 9-amino-daca, dna
• Total number of polymer chains: 1
• Total formula weight: 2425.97

Authors

Adams, A.,Guss, J.M.,Collyer, C.A.,Denny, W.A.,Wakelin, L.P. (deposition date: 1999-04-14, release date: 1999-08-25, Last modification date: 2024-04-03)

• Primary citation: Adams, A.,Guss, J.M.,Collyer, C.A.,Denny, W.A.,Wakelin, L.P.; Crystal structure of the topoisomerase II poison 9-amino-[N-(2-dimethylamino)ethyl]acridine-4-carboxamide bound to the DNA hexanucleotide d(CGTACG)2.; Biochemistry, 38:9221-9233, 1999; PubMed: 10413496; DOI: 10.1021/bi990352m

Experimental method

X-RAY DIFFRACTION (1.6 Å)