426D

THE STRUCTURE OF MOST STUDIED DNA FRAGMENT CHANGES UNDER THE INFLUENCE OF IONS: A NEW PACKING OF D(CGCGAATTCGCG)

Summary for 426D

• Entry DOI: 10.2210/pdb426d/pdb
• Descriptor: 5'-D(CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3', CALCIUM ION (3 entities in total)
• Functional Keywords: double helix, dna
• Total number of polymer chains: 2
• Total formula weight: 7366.86

Authors

Liu, J.,Malinina, L.,Subirana, J.A. (deposition date: 1998-09-17, release date: 1998-11-30, Last modification date: 2024-02-28)

Primary citation

Liu, J.,Malinina, L.,Huynh-Dinh, T.,Subirana, J.A.
The structure of the most studied DNA fragment changes under the influence of ions: a new packing of d(CGCGAATTCGCG).
FEBS Lett., 438:211-214, 1998

PubMed Abstract: The title oligonucleotide and many related dodecamers have been extensively studied alone and as DNA-drug complexes. In practically all cases they were found to crystallize in the same space group, stabilized by interactions among the terminal guanine bases. Here we report new packing interactions (R3) in the presence of Ca2+. The oligonucleotides interact by placing their terminal guanines in the narrow groove of a neighbor molecule, an interaction which had never been found in dodecamers.

PubMed: 9827547
DOI: 10.1016/S0014-5793(98)01295-2

Experimental method

X-RAY DIFFRACTION (3 Å)