426D

THE STRUCTURE OF MOST STUDIED DNA FRAGMENT CHANGES UNDER THE INFLUENCE OF IONS: A NEW PACKING OF D(CGCGAATTCGCG)

426D の概要

• エントリーDOI: 10.2210/pdb426d/pdb
• 分子名称: 5'-D(CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3', CALCIUM ION (3 entities in total)
• 機能のキーワード: double helix, dna
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 7366.86

構造登録者

Liu, J.,Malinina, L.,Subirana, J.A. (登録日: 1998-09-17, 公開日: 1998-11-30, 最終更新日: 2024-02-28)

主引用文献

Liu, J.,Malinina, L.,Huynh-Dinh, T.,Subirana, J.A.
The structure of the most studied DNA fragment changes under the influence of ions: a new packing of d(CGCGAATTCGCG).
FEBS Lett., 438:211-214, 1998

PubMed Abstract: The title oligonucleotide and many related dodecamers have been extensively studied alone and as DNA-drug complexes. In practically all cases they were found to crystallize in the same space group, stabilized by interactions among the terminal guanine bases. Here we report new packing interactions (R3) in the presence of Ca2+. The oligonucleotides interact by placing their terminal guanines in the narrow groove of a neighbor molecule, an interaction which had never been found in dodecamers.

PubMed: 9827547
DOI: 10.1016/S0014-5793(98)01295-2

実験手法

X-RAY DIFFRACTION (3 Å)