407D
STRUCTURAL BASIS FOR RECOGNITION OF A-T AND T-A BASE PAIRS IN THE MINOR GROOVE OF B-DNA
Summary for 407D
Entry DOI | 10.2210/pdb407d/pdb |
Descriptor | DNA (5'-D(*CP*CP*AP*GP*TP*AP*CP*TP*GP*G)-3'), ~{N}-[5-[[5-[[5-[[3-[3-(dimethylamino)propylamino]-3-oxidanylidene-propyl]carbamoyl]-1-methyl-pyrrol-3-yl]carbamoyl]-1-methyl-pyrrol-3-yl]carbamoyl]-1-methyl-4-oxidanyl-pyrrol-3-yl]-1-methyl-imidazole-2-carboxamide, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (4 entities in total) |
Functional Keywords | drugs in the dna minor groove, dna |
Biological source | synthetic construct |
Total number of polymer chains | 2 |
Total formula weight | 7539.60 |
Authors | Rees, D.C. (deposition date: 1998-06-24, release date: 1998-10-19, Last modification date: 2024-02-28) |
Primary citation | Kielkopf, C.L.,White, S.,Szewczyk, J.W.,Turner, J.M.,Baird, E.E.,Dervan, P.B.,Rees, D.C. A structural basis for recognition of A.T and T.A base pairs in the minor groove of B-DNA. Science, 282:111-115, 1998 Cited by PubMed: 9756473DOI: 10.1126/science.282.5386.111 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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