3ZVS

Crystal structure of Archaemetzincin (AmzA) from Archaeoglobus fulgidus at 1.4 A resolution complexed with malonate

Summary for 3ZVS

• Entry DOI: 10.2210/pdb3zvs/pdb
• Related: 2XHQ 4A3W 4AXQ
• Descriptor: ARCHAEMETZINCIN, ZINC ION, MALONATE ION, ... (4 entities in total)
• Functional Keywords: metalloprotease, protease, hydrolase, metzincin, metal-binding
• Biological source: ARCHAEOGLOBUS FULGIDUS
• Total number of polymer chains: 3
• Total formula weight: 54539.19

Authors

Graef, C.,Schacherl, M.,Baumann, U. (deposition date: 2011-07-27, release date: 2012-08-08, Last modification date: 2024-11-13)

Primary citation

Graef, C.,Schacherl, M.,Waltersperger, S.,Baumann, U.
Crystal Structures of Archaemetzincin Reveal a Moldable Substrate-Binding Site.
Plos One, 7:43863-, 2012

PubMed Abstract: Archaemetzincins are metalloproteases occurring in archaea and some mammalia. They are distinct from all the other metzincins by their extended active site consensus sequence HEXXHXXGXXHCX(4)CXMX(17)CXXC featuring four conserved cysteine residues. Very little is known about their biological importance and structure-function relationships.

PubMed: 22937112
DOI: 10.1371/JOURNAL.PONE.0043863

Experimental method

X-RAY DIFFRACTION (1.396 Å)