3ZVS

Crystal structure of Archaemetzincin (AmzA) from Archaeoglobus fulgidus at 1.4 A resolution complexed with malonate

3ZVS の概要

• エントリーDOI: 10.2210/pdb3zvs/pdb
• 関連するPDBエントリー: 2XHQ 4A3W 4AXQ
• 分子名称: ARCHAEMETZINCIN, ZINC ION, MALONATE ION, ... (4 entities in total)
• 機能のキーワード: metalloprotease, protease, hydrolase, metzincin, metal-binding
• 由来する生物種: ARCHAEOGLOBUS FULGIDUS
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 54539.19

構造登録者

Graef, C.,Schacherl, M.,Baumann, U. (登録日: 2011-07-27, 公開日: 2012-08-08, 最終更新日: 2024-11-13)

主引用文献

Graef, C.,Schacherl, M.,Waltersperger, S.,Baumann, U.
Crystal Structures of Archaemetzincin Reveal a Moldable Substrate-Binding Site.
Plos One, 7:43863-, 2012

PubMed Abstract: Archaemetzincins are metalloproteases occurring in archaea and some mammalia. They are distinct from all the other metzincins by their extended active site consensus sequence HEXXHXXGXXHCX(4)CXMX(17)CXXC featuring four conserved cysteine residues. Very little is known about their biological importance and structure-function relationships.

PubMed: 22937112
DOI: 10.1371/JOURNAL.PONE.0043863

実験手法

X-RAY DIFFRACTION (1.396 Å)