3ZQ6

ADP-ALF4 COMPLEX OF M. THERM. TRC40

3ZQ6 の概要

• エントリーDOI: 10.2210/pdb3zq6/pdb
• 分子名称: PUTATIVE ARSENICAL PUMP-DRIVING ATPASE, ADENOSINE-5'-DIPHOSPHATE, TETRAFLUOROALUMINATE ION, ... (7 entities in total)
• 機能のキーワード: tail-anchored, membrane protein, targeting factor atp-binding, arsa, nucleotide-binding, hydrolase
• 由来する生物種: METHANOTHERMOBACTER THERMAUTOTROPHICUS
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 148860.67

構造登録者

Sherrill, J.,Mariappan, M.,Dominik, P.,Hegde, R.S.,Keenan, R.J. (登録日: 2011-06-08, 公開日: 2011-06-22, 最終更新日: 2023-12-20)

主引用文献

Sherrill, J.,Mariappan, M.,Dominik, P.,Hegde, R.S.,Keenan, R.J.
A Conserved Archaeal Pathway for Tail-Anchored Membrane Protein Insertion.
Traffic, 12:1119-, 2011

PubMed Abstract: Eukaryotic tail-anchored (TA) membrane proteins are inserted into the endoplasmic reticulum by a post-translational TRC40 pathway, but no comparable pathway is known in other domains of life. The crystal structure of an archaebacterial TRC40 sequence homolog bound to ADP•AlF(4) (-) reveals characteristic features of eukaryotic TRC40, including a zinc-mediated dimer and a large hydrophobic groove. Moreover, archaeal TRC40 interacts with the transmembrane domain of TA substrates and directs their membrane insertion. Thus, the TRC40 pathway is more broadly conserved than previously recognized.

PubMed: 21658170
DOI: 10.1111/J.1600-0854.2011.01229.X

実験手法

X-RAY DIFFRACTION (2.107 Å)