3ZOS

Structure of the DDR1 kinase domain in complex with ponatinib

3ZOS の概要

• エントリーDOI: 10.2210/pdb3zos/pdb
• 分子名称: EPITHELIAL DISCOIDIN DOMAIN-CONTAINING RECEPTOR 1, 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: transferase, rtk, collagen, discoidin domain
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Single-pass type I membrane protein. Isoform 3: Secreted . Isoform 4: Cell membrane; Single-pass type I membrane protein: Q08345
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 73292.07

構造登録者

Canning, P.,Elkins, J.M.,Goubin, S.,Mahajan, P.,Bradley, A.,Coutandin, D.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A. (登録日: 2013-02-22, 公開日: 2013-05-01, 最終更新日: 2023-12-20)

• 主引用文献: Canning, P.,Elkins, J.M.,Goubin, S.,Mahajan, P.,Bradley, A.,Coutandin, D.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.; Structural Mechanisms Determining Inhibition of the Collagen Receptor Ddr1 by Selective and Multi-Targeted Type II Kinase Inhibitors; J.Mol.Biol., 426:2457-, 2014; PubMed: 24768818; DOI: 10.1016/J.JMB.2014.04.014

実験手法

X-RAY DIFFRACTION (1.92 Å)