3ZN4

VP16, a capsid protein of bacteriophage P23-77 (VP16-type-2)

3ZN4 の概要

• エントリーDOI: 10.2210/pdb3zn4/pdb
• 関連するPDBエントリー: 3ZMN 3ZMO 3ZN5 3ZN6
• 分子名称: VP16, CITRIC ACID, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: viral protein
• 由来する生物種: THERMUS PHAGE P23-77
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 19355.35

構造登録者

Rissanen, I.,Grimes, J.M.,Pawlowski, A.,Mantynen, S.,Harlos, K.,Bamford, J.K.H.,Stuart, D.I. (登録日: 2013-02-13, 公開日: 2013-05-15, 最終更新日: 2023-12-20)

主引用文献

Rissanen, I.,Grimes, J.M.,Pawlowski, A.,Mantynen, S.,Harlos, K.,Bamford, J.K.H.,Stuart, D.I.
Bacteriophage P23-77 Capsid Protein Structures Reveal the Archetype of an Ancient Branch from a Major Virus Lineage.
Structure, 21:718-, 2013

PubMed Abstract: It has proved difficult to classify viruses unless they are closely related since their rapid evolution hinders detection of remote evolutionary relationships in their genetic sequences. However, structure varies more slowly than sequence, allowing deeper evolutionary relationships to be detected. Bacteriophage P23-77 is an example of a newly identified viral lineage, with members inhabiting extreme environments. We have solved multiple crystal structures of the major capsid proteins VP16 and VP17 of bacteriophage P23-77. They fit the 14 Å resolution cryo-electron microscopy reconstruction of the entire virus exquisitely well, allowing us to propose a model for both the capsid architecture and viral assembly, quite different from previously published models. The structures of the capsid proteins and their mode of association to form the viral capsid suggest that the P23-77-like and adeno-PRD1 lineages of viruses share an extremely ancient common ancestor.

PubMed: 23623731
DOI: 10.1016/J.STR.2013.02.026

実験手法

X-RAY DIFFRACTION (1.26 Å)