3ZMK

Anopheles funestus glutathione-s-transferase epsilon 2 (GSTe2) protein structure from different alelles: A single amino acid change confers high level of DDT resistance and cross resistance to permethrin in a major malaria vector in Africa

3ZMK の概要

• エントリーDOI: 10.2210/pdb3zmk/pdb
• 関連するPDBエントリー: 3ZML
• 分子名称: GLUTATHIONE S-TRANSFERASE E2, GLUTATHIONE (3 entities in total)
• 機能のキーワード: transferase, benin allele
• 由来する生物種: ANOPHELES FUNESTUS
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 101826.71

構造登録者

Yunta, C.,Albert, A. (登録日: 2013-02-11, 公開日: 2014-01-22, 最終更新日: 2023-12-20)

主引用文献

Riveron, J.M.,Yunta, C.,Ibrahim, S.S.,Djouaka, R.,Irving, H.,Menze, B.D.,Ismail, H.M.,Hemingway, J.,Ranson, H.,Albert, A.,Wondji, C.S.
A Single Mutation in the Gste2 Gene Allows Tracking of Metabolically-Based Insecticide Resistance in a Major Malaria Vector.
Genome Biol., 15:R27-, 2014

PubMed Abstract: Metabolic resistance to insecticides is the biggest threat to the continued effectiveness of malaria vector control. However, its underlying molecular basis, crucial for successful resistance management, remains poorly characterized.

PubMed: 24565444
DOI: 10.1186/GB-2014-15-2-R27

実験手法

X-RAY DIFFRACTION (2.2 Å)