3ZM9

The mechanism of allosteric coupling in choline kinase a1 revealed by a rationally designed inhibitor

3ZM9 の概要

• エントリーDOI: 10.2210/pdb3zm9/pdb
• 分子名称: CHOLINE KINASE ALPHA, 1-(4-(4-(4-((6-amino-9H-purin-9-yl)methyl)phenyl)butyl)benzyl)-4- (dimethylamino)pyridinium (3 entities in total)
• 機能のキーワード: transferase, negative cooperativity, allosteric mechanism, elastic network analysis
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Cytoplasm: P35790
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 90894.19

構造登録者

Sahun-Roncero, M.,Rubio-Ruiz, B.,Saladino, G.,Conejo-Garcia, A.,Espinosa, A.,Velazquez-Campoy, A.,Gervasio, F.L.,Entrena, A.,Hurtado-Guerrero, R. (登録日: 2013-02-06, 公開日: 2013-02-27, 最終更新日: 2023-12-20)

• 主引用文献: Sahun-Roncero, M.,Rubio-Ruiz, B.,Saladino, G.,Conejo-Garcia, A.,Espinosa, A.,Velazquez-Campoy, A.,Gervasio, F.L.,Entrena, A.,Hurtado-Guerrero, R.; The Mechanism of Allosteric Coupling in Choline Kinase A1 Revealed by a Rationally Designed Inhibitor; Angew.Chem.Int.Ed.Engl., 52:4582-, 2013; PubMed: 23441033; DOI: 10.1002/ANIE.201209660

実験手法

X-RAY DIFFRACTION (1.9 Å)