3ZM5

CRYSTAL STRUCTURE OF MURF LIGASE IN COMPLEX WITH CYANOTHIOPHENE INHIBITOR

3ZM5 の概要

• エントリーDOI: 10.2210/pdb3zm5/pdb
• 関連するPDBエントリー: 3ZL8 3ZM6
• 分子名称: UDP-N-ACETYLMURAMOYL-TRIPEPTIDE--D-ALANYL-D-ALANINE LIGASE, 2,4-bis(chloranyl)-N-[3-cyano-6-[(4-hydroxyphenyl)methyl]-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl]-5-morpholin-4-ylsulfonyl-benzamide (3 entities in total)
• 機能のキーワード: ligase, peptidoglycan synthesis, adp-forming enzyme, cell wall, cell shape, cell cycle, cell divison, nucleotide-binding, atp-binding
• 由来する生物種: STREPTOCOCCUS PNEUMONIAE R6
• 細胞内の位置: Cytoplasm (By similarity): Q8DNV6
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 52237.94

構造登録者

Hrast, M.,Turk, S.,Sosic, I.,Knez, D.,Randall, C.P.,Barreteau, H.,Contreras-Martel, C.,Dessen, A.,ONeill, A.J.,Mengin-Lecreulx, D.,Blanot, D.,Gobec, S. (登録日: 2013-02-05, 公開日: 2013-07-03, 最終更新日: 2023-12-20)

• 主引用文献: Hrast, M.,Turk, S.,Sosic, I.,Knez, D.,Randall, C.P.,Barreteau, H.,Contreras-Martel, C.,Dessen, A.,O'Neill, A.J.,Mengin-Lecreulx, D.,Blanot, D.,Gobec, S.; Structure-Activity Relationships of New Cyanothiophene Inhibitors of the Essential Peptidoglycan Biosynthesis Enzyme Murf.; Eur.J.Med.Chem., 66C:32-, 2013; PubMed: 23786712; DOI: 10.1016/J.EJMECH.2013.05.013

実験手法

X-RAY DIFFRACTION (2.94 Å)