3ZH8

A novel small molecule aPKC inhibitor

3ZH8 の概要

• エントリーDOI: 10.2210/pdb3zh8/pdb
• 分子名称: PROTEIN KINASE C IOTA TYPE, IODIDE ION, CHLORIDE ION, ... (6 entities in total)
• 機能のキーワード: transferase, agc kinases, cell polarity, cell migration
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 124448.51

構造登録者

Kjaer, S.,Purkiss, A.G.,Kostelecky, B.,Knowles, P.P.,Soriano, E.,Murray-Rust, J.,McDonald, N.Q. (登録日: 2012-12-20, 公開日: 2013-02-27, 最終更新日: 2023-12-20)

• 主引用文献: Kjaer, S.,Linch, M.,Purkiss, A.,Kostelecky, B.,Knowles, P.P.,Rosse, C.,Riou, P.,Soudy, C.,Kaye, S.,Patel, B.,Soriano, E.,Murray-Rust, J.,Barton, C.,Dillon, C.,Roffey, J.,Parker, P.J.,Mcdonald, N.Q.; Adenosine-Binding Motif Mimicry and Cellular Effects of a Thieno[2,3-D]Pyrimidine-Based Chemical Inhibitor of Atypical Protein Kinase C Isozymes.; Biochem.J., 451:329-, 2013; PubMed: 23418854; DOI: 10.1042/BJ20121871

実験手法

X-RAY DIFFRACTION (2.739 Å)