3ZG6

The novel de-long chain fatty acid function of human sirt6

Summary for 3ZG6

• Entry DOI: 10.2210/pdb3zg6/pdb
• Descriptor: NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-6, PEPTIDE, ZINC ION, ... (6 entities in total)
• Functional Keywords: hydrolase-inhibitor complex, sirtuin class iii, hdacs nad dependent, hydrolase/inhibitor
• Biological source: HOMO SAPIENS; More
• Cellular location: Nucleus, nucleoplasm: Q8N6T7
• Total number of polymer chains: 2
• Total formula weight: 35317.68

Authors

Wang, Y.,Hao, Q. (deposition date: 2012-12-15, release date: 2013-04-03, Last modification date: 2013-04-17)

• Primary citation: Jiang, H.,Khan, S.,Wang, Y.,Charron, G.,He, B.,Sebastian, C.,Du, J.,Kim, R.,Ge, E.,Mostoslavsky, R.,Hang, H.C.,Hao, Q.,Lin, H.; Sirt6 Regulates Tnf-Alpha Secretion Through Hydrolysis of Long-Chain Fatty Acyl Lysine; Nature, 496:110-, 2013; PubMed: 23552949; DOI: 10.1038/NATURE12038

Experimental method

X-RAY DIFFRACTION (2.2 Å)