3ZEI

Structure of the Mycobacterium tuberculosis O-Acetylserine Sulfhydrylase (OASS) CysK1 in complex with a small molecule inhibitor

3ZEI の概要

• エントリーDOI: 10.2210/pdb3zei/pdb
• 分子名称: O-ACETYLSERINE SULFHYDRYLASE, PYRIDOXAL-5'-PHOSPHATE, 3-[(Z)-[(5Z)-5-[[2-(2-hydroxy-2-oxoethyloxy)phenyl]methylidene]-3-methyl-4-oxidanylidene-1,3-thiazolidin-2-ylidene]amino]benzoic acid, ... (5 entities in total)
• 機能のキーワード: hydrolase, inhibitor
• 由来する生物種: MYCOBACTERIUM TUBERCULOSIS
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33681.52

構造登録者

Poyraz, O.,Schnell, R.,Schneider, G. (登録日: 2012-12-05, 公開日: 2013-08-07, 最終更新日: 2023-12-20)

• 主引用文献: Poyraz, O.,Jeankumar, V.U.,Saxena, S.,Schnell, R.,Haraldsson, M.,Yogeeswari, P.,Sriram, D.,Schneider, G.; Structure-Guided Design of Novel Thiazolidine Inhibitors of O-Acetyl Serine Sulfhydrylase from Mycobacterium Tuberculosis.; J.Med.Chem., 56:6457-, 2013; PubMed: 23879381; DOI: 10.1021/JM400710K

実験手法

X-RAY DIFFRACTION (2 Å)