3ZDU

Crystal structure of the human CDKL3 kinase domain

Summary for 3ZDU

Entry DOI	10.2210/pdb3zdu/pdb
Descriptor	CYCLIN-DEPENDENT KINASE-LIKE 3, [4-({4-[(3-cyclopentyl-1H-pyrazol-5-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrile, ZINC ION, ... (6 entities in total)
Functional Keywords	transferase, phospho-mimetic
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cytoplasm : Q8IVW4
Total number of polymer chains	1
Total formula weight	37988.75
Authors	Canning, P.,Elkins, J.M.,Goubin, S.,Mahajan, P.,Pike, A.C.W.,Quigley, A.,MacKenzie, A.,Carpenter, E.P.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A. (deposition date: 2012-11-30, release date: 2013-03-20, Last modification date: 2023-12-20)
Primary citation	Canning, P.,Park, K.,Goncalves, J.,Li, C.,Howard, C.J.,Sharpe, T.D.,Holt, L.J.,Pelletier, L.,Bullock, A.N.,Leroux, M.R. CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function. Cell Rep, 22:885-894, 2018 Cited by PubMed: 29420175 DOI: 10.1016/j.celrep.2017.12.083 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation