3ZDI
Glycogen Synthase Kinase 3 Beta complexed with Axin Peptide and Inhibitor 7d
Summary for 3ZDI
Entry DOI | 10.2210/pdb3zdi/pdb |
Descriptor | GLYCOGEN SYNTHASE KINASE-3 BETA, AXIN-1, PHOSPHATE ION, ... (5 entities in total) |
Functional Keywords | transferase-peptide complex, insulin pathway, wnt signaling pathway, transferase serine/threonine-protein kinase, inhibitor, transferase/peptide |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Cytoplasm: P49841 O15169 |
Total number of polymer chains | 2 |
Total formula weight | 42442.95 |
Authors | Oberholzer, A.E.,Pearl, L.H. (deposition date: 2012-11-27, release date: 2012-12-26, Last modification date: 2024-10-09) |
Primary citation | Fugel, W.,Oberholzer, A.E.,Gschloessl, B.,Dzikowski, R.,Pressburger, N.,Preu, L.,Pearl, L.H.,Baratte, B.,Ratin, M.,Okun, I.,Doerig, C.,Kruggel, S.,Lemcke, T.,Meijer, L.,Kunick, C. 3,6-Diamino-4-(2-Halophenyl)-2-Benzoylthieno(2,3-B) Pyridine-5-Carbonitriles are Selective Inhibitors of Plasmodium Falciparum Glycogen Synthase Kinase-3 (Pfgsk-3) J.Med.Chem., 56:264-, 2013 Cited by PubMed: 23214499DOI: 10.1021/JM301575N PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.645 Å) |
Structure validation
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