3ZDI

Glycogen Synthase Kinase 3 Beta complexed with Axin Peptide and Inhibitor 7d

3ZDI の概要

• エントリーDOI: 10.2210/pdb3zdi/pdb
• 分子名称: GLYCOGEN SYNTHASE KINASE-3 BETA, AXIN-1, PHOSPHATE ION, ... (5 entities in total)
• 機能のキーワード: transferase-peptide complex, insulin pathway, wnt signaling pathway, transferase serine/threonine-protein kinase, inhibitor, transferase/peptide
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• 細胞内の位置: Cytoplasm: P49841 O15169
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 42442.95

構造登録者

Oberholzer, A.E.,Pearl, L.H. (登録日: 2012-11-27, 公開日: 2012-12-26, 最終更新日: 2024-10-09)

• 主引用文献: Fugel, W.,Oberholzer, A.E.,Gschloessl, B.,Dzikowski, R.,Pressburger, N.,Preu, L.,Pearl, L.H.,Baratte, B.,Ratin, M.,Okun, I.,Doerig, C.,Kruggel, S.,Lemcke, T.,Meijer, L.,Kunick, C.; 3,6-Diamino-4-(2-Halophenyl)-2-Benzoylthieno(2,3-B) Pyridine-5-Carbonitriles are Selective Inhibitors of Plasmodium Falciparum Glycogen Synthase Kinase-3 (Pfgsk-3); J.Med.Chem., 56:264-, 2013; PubMed: 23214499; DOI: 10.1021/JM301575N

実験手法

X-RAY DIFFRACTION (2.645 Å)