3ZCZ

Crystal structure of a complex between Actinomadura R39 DD-peptidase and a trifluoroketone inhibitor

3ZCZ の概要

• エントリーDOI: 10.2210/pdb3zcz/pdb
• 分子名称: D-ALANYL-D-ALANINE CARBOXYPEPTIDASE, (2R)-2-amino-7-oxo-7-{[(2R,3S)-4,4,4-trifluoro-3-hydroxybutan-2-yl]amino}heptanoic acid, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: hydrolase, inhibitor, peptidoglycan
• 由来する生物種: ACTINOMADURA SP. R39
• 細胞内の位置: Secreted: P39045
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 193843.67

構造登録者

Sauvage, E.,Herman, R.,Kerff, F.,Rocaboy, M.,Charlier, P. (登録日: 2012-11-23, 公開日: 2013-03-27, 最終更新日: 2023-12-20)

• 主引用文献: Dzhekieva, L.,Adediran, S.A.,Herman, R.,Kerff, F.,Duez, C.,Charlier, P.,Sauvage, E.,Pratt, R.F.; Inhibition of Dd-Peptidases by a Specific Trifluoroketone: Crystal Structure of a Complex with the Actinomadura R39 Dd-Peptidase.; Biochemistry, 52:2128-, 2013; PubMed: 23484909; DOI: 10.1021/BI400048S

実験手法

X-RAY DIFFRACTION (2.6 Å)