3ZCW

Eg5 - New allosteric binding site

Summary for 3ZCW

DescriptorKINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (7 entities in total)
Functional Keywordscell cycle, inhibitor
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationCytoplasm P52732
Total number of polymer chains1
Total molecular weight40521.78
Authors
Ulaganathan, V.,Talapatra, S.K.,Kozielski, F.,Pannifer, A.D. (deposition date: 2012-11-23, release date: 2013-01-23, Last modification date: 2013-02-27)
Primary citation
Ulaganathan, V.,Talapatra, S.K.,Rath, O.,Pannifer, A.D.,Hackney, D.D.,Kozielski, F.
Structural Insights Into a Unique Inhibitor Binding Pocket in Kinesin Spindle Protein.
J.Am.Chem.Soc., 135:2263-, 2013
PubMed: 23305346 (PDB entries with the same primary citation)
DOI: 10.1021/JA310377D
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.691 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.226110.6%2.5%9.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution