3ZBF

Structure of Human ROS1 Kinase Domain in Complex with Crizotinib

Summary for 3ZBF

Entry DOI	10.2210/pdb3zbf/pdb
Descriptor	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ROS, 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine (3 entities in total)
Functional Keywords	transferase, tyrosine kinase
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	37464.82
Authors	McTigue, M.,Deng, Y.,Liu, W.,Brooun, A.,Stewart, A. (deposition date: 2012-11-08, release date: 2013-06-12, Last modification date: 2023-12-20)
Primary citation	Awad, M.M.,Katayama, R.,Mctigue, M.,Liu, W.,Deng, Y.,Brooun, A.,Friboulet, L.,Huang, D.,Falk, M.D.,Timofeevski, S.,Wilner, K.D.,Lockerman, E.L.,Khan, T.M.,Mahmood, S.,Gainor, J.F.,Digumarthy, S.R.,Stone, J.R.,Mino-Kenudson, M.,Christensen, J.G.,Iafrate, J.,Engelman, J.A.,Shaw, A.T. Acquired Resistance to Crizotinib from a Mutation in Cd74-Ros1 N.Engl.J.Med., 368:2395-, 2013 Cited by PubMed: 23724914 DOI: 10.1056/NEJMOA1215530 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation