3X03

Crystal structure of PIP4KIIBETA complex with AMPPNP

Summary for 3X03

Related3WZZ 3X01 3X02 3X04 3X05 3X06 3X07 3X08 3X09 3X0A 3X0B 3X0C
DescriptorPhosphatidylinositol 5-phosphate 4-kinase type-2 beta, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER (3 entities in total)
Functional Keywordslipid kinase, phosphoinositide signaling, transferase
Biological sourceHomo sapiens (human)
Cellular locationEndoplasmic reticulum membrane ; Peripheral membrane protein  P78356
Total number of polymer chains2
Total molecular weight91376.39
Authors
Primary citation
Sumita, K.,Lo, Y.H.,Takeuchi, K.,Senda, M.,Kofuji, S.,Ikeda, Y.,Terakawa, J.,Sasaki, M.,Yoshino, H.,Majd, N.,Zheng, Y.,Kahoud, E.R.,Yokota, T.,Emerling, B.M.,Asara, J.M.,Ishida, T.,Locasale, J.W.,Daikoku, T.,Anastasiou, D.,Senda, T.,Sasaki, A.T.
The Lipid Kinase PI5P4K beta Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis
Mol.Cell, 61:187-198, 2016
PubMed: 26774281 (PDB entries with the same primary citation)
DOI: 10.1016/j.molcel.2015.12.011
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.7 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.261170.5%6.1%7.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution