3WSA
The Tuberculosis Drug SQ109 Inhibits Trypanosoma cruzi Cell Proliferation and acts Synergistically with Posaconazole
Summary for 3WSA
Entry DOI | 10.2210/pdb3wsa/pdb |
Related | 3WSB |
Descriptor | Squalene synthase, N-[(2Z)-3,7-dimethylocta-2,6-dien-1-yl]-N'-[(1R,3S,5R,7R)-tricyclo[3.3.1.1~3,7~]dec-2-yl]ethane-1,2-diamine (3 entities in total) |
Functional Keywords | isoprenoids, drug discovery, human squalene synthase, transferase, sq-109 |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane; Multi-pass membrane protein: P37268 |
Total number of polymer chains | 6 |
Total formula weight | 249056.13 |
Authors | Shang, N.,Li, Q.,Huang, C.H.,Oldfield, E.,Guo, R.T. (deposition date: 2014-03-05, release date: 2015-04-01, Last modification date: 2024-03-13) |
Primary citation | Veiga-Santos, P.,Li, K.,Lameira, L.,de Carvalho, T.M.,Huang, G.,Galizzi, M.,Shang, N.,Li, Q.,Gonzalez-Pacanowska, D.,Hernandez-Rodriguez, V.,Benaim, G.,Guo, R.T.,Urbina, J.A.,Docampo, R.,de Souza, W.,Oldfield, E. SQ109, a new drug lead for Chagas disease. Antimicrob.Agents Chemother., 59:1950-1961, 2015 Cited by PubMed: 25583723DOI: 10.1128/AAC.03972-14 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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