3WSA

The Tuberculosis Drug SQ109 Inhibits Trypanosoma cruzi Cell Proliferation and acts Synergistically with Posaconazole

Summary for 3WSA

• Entry DOI: 10.2210/pdb3wsa/pdb
• Related: 3WSB
• Descriptor: Squalene synthase, N-[(2Z)-3,7-dimethylocta-2,6-dien-1-yl]-N'-[(1R,3S,5R,7R)-tricyclo[3.3.1.1~3,7~]dec-2-yl]ethane-1,2-diamine (3 entities in total)
• Functional Keywords: isoprenoids, drug discovery, human squalene synthase, transferase, sq-109
• Biological source: Homo sapiens (human)
• Cellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein: P37268
• Total number of polymer chains: 6
• Total formula weight: 249056.13

Authors

Shang, N.,Li, Q.,Huang, C.H.,Oldfield, E.,Guo, R.T. (deposition date: 2014-03-05, release date: 2015-04-01, Last modification date: 2024-03-13)

• Primary citation: Veiga-Santos, P.,Li, K.,Lameira, L.,de Carvalho, T.M.,Huang, G.,Galizzi, M.,Shang, N.,Li, Q.,Gonzalez-Pacanowska, D.,Hernandez-Rodriguez, V.,Benaim, G.,Guo, R.T.,Urbina, J.A.,Docampo, R.,de Souza, W.,Oldfield, E.; SQ109, a new drug lead for Chagas disease.; Antimicrob.Agents Chemother., 59:1950-1961, 2015; PubMed: 25583723; DOI: 10.1128/AAC.03972-14

Experimental method

X-RAY DIFFRACTION (2.9 Å)