3WQT

Staphylococcus aureus FtsA complexed with AMPPNP

3WQT の概要

• エントリーDOI: 10.2210/pdb3wqt/pdb
• 関連するPDBエントリー: 3WQU
• 分子名称: Cell division protein FtsA, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (5 entities in total)
• 機能のキーワード: actin-like fold, structural genomics
• 由来する生物種: Staphylococcus aureus subsp. aureus
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 221579.63

構造登録者

Fujita, J.,Maeda, Y.,Miyazaki, Y.,Inoue, T.,Matsumura, H. (登録日: 2014-02-01, 公開日: 2014-10-08, 最終更新日: 2024-03-20)

主引用文献

Fujita, J.,Maeda, Y.,Nagao, C.,Tsuchiya, Y.,Miyazaki, Y.,Hirose, M.,Mizohata, E.,Matsumoto, Y.,Inoue, T.,Mizuguchi, K.,Matsumura, H.
Crystal structure of FtsA from Staphylococcus aureus
FEBS Lett., 588:1879-1885, 2014

PubMed Abstract: The bacterial cell-division protein FtsA anchors FtsZ to the cytoplasmic membrane. But how FtsA and FtsZ interact during membrane division remains obscure. We have solved 2.2 Å resolution crystal structure for FtsA from Staphylococcus aureus. In the crystals, SaFtsA molecules within the dimer units are twisted, in contrast to the straight filament of FtsA from Thermotoga maritima, and the half of S12-S13 hairpin regions are disordered. We confirmed that SaFtsZ and SaFtsA associate in vitro, and found that SaFtsZ GTPase activity is enhanced by interaction with SaFtsA.

PubMed: 24746687
DOI: 10.1016/j.febslet.2014.04.008

実験手法

X-RAY DIFFRACTION (2.2 Å)