3WQH

Crystal Structure of human DPP-IV in complex with Anagliptin

Summary for 3WQH

Entry DOI	10.2210/pdb3wqh/pdb
Descriptor	Dipeptidyl peptidase 4, 2-acetamido-2-deoxy-beta-D-glucopyranose, N-[2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)-2-methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide, ... (4 entities in total)
Functional Keywords	diabetes, beta-propeller, aminopeptidase, membrane, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	172876.16
Authors	Watanabe, Y.S.,Okada, S.,Motoyama, T.,Takahashi, R.,Adachi, H.,Oka, M. (deposition date: 2014-01-27, release date: 2015-07-15, Last modification date: 2023-11-08)
Primary citation	Watanabe, Y.S.,Yasuda, Y.,Kojima, Y.,Okada, S.,Motoyama, T.,Takahashi, R.,Oka, M. Anagliptin, a potent dipeptidyl peptidase IV inhibitor: its single-crystal structure and enzyme interactions. J Enzyme Inhib Med Chem, 30:981-988, 2015 Cited by PubMed: 26147347 DOI: 10.3109/14756366.2014.1002402 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.85 Å)

Structure validation