3WQH

Crystal Structure of human DPP-IV in complex with Anagliptin

3WQH の概要

• エントリーDOI: 10.2210/pdb3wqh/pdb
• 分子名称: Dipeptidyl peptidase 4, 2-acetamido-2-deoxy-beta-D-glucopyranose, N-[2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)-2-methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide, ... (4 entities in total)
• 機能のキーワード: diabetes, beta-propeller, aminopeptidase, membrane, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 172876.16

構造登録者

Watanabe, Y.S.,Okada, S.,Motoyama, T.,Takahashi, R.,Adachi, H.,Oka, M. (登録日: 2014-01-27, 公開日: 2015-07-15, 最終更新日: 2023-11-08)

• 主引用文献: Watanabe, Y.S.,Yasuda, Y.,Kojima, Y.,Okada, S.,Motoyama, T.,Takahashi, R.,Oka, M.; Anagliptin, a potent dipeptidyl peptidase IV inhibitor: its single-crystal structure and enzyme interactions.; J Enzyme Inhib Med Chem, 30:981-988, 2015; PubMed: 26147347; DOI: 10.3109/14756366.2014.1002402

実験手法

X-RAY DIFFRACTION (2.85 Å)