3WJL

Crystal structure of IIb selective Fc variant, Fc(V12), in complex with FcgRIIb

3WJL の概要

• エントリーDOI: 10.2210/pdb3wjl/pdb
• 関連するPDBエントリー: 3WJJ
• 分子名称: Ig gamma-1 chain C region, Low affinity immunoglobulin gamma Fc region receptor II-c, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: receptor complex, fc receptor, antibody, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 75602.10

構造登録者

Kadono, S.,Mimoto, F.,Katada, H.,Igawa, T.,Kuramochi, T.,Muraoka, M.,Wada, Y.,Haraya, K.,Miyazaki, T.,Hattori, K. (登録日: 2013-10-11, 公開日: 2013-11-13, 最終更新日: 2023-11-29)

• 主引用文献: Mimoto, F.,Katada, H.,Kadono, S.,Igawa, T.,Kuramochi, T.,Muraoka, M.,Wada, Y.,Haraya, K.,Miyazaki, T.,Hattori, K.; Engineered antibody Fc variant with selectively enhanced Fc gamma RIIb binding over both Fc gamma RIIaR131 and Fc gamma RIIaH131.; Protein Eng.Des.Sel., 26:589-598, 2013; PubMed: 23744091; DOI: 10.1093/protein/gzt022

実験手法

X-RAY DIFFRACTION (2.86 Å)