3WI2
Crystal structure of PDE10A in complex with inhibitor
Summary for 3WI2
Entry DOI | 10.2210/pdb3wi2/pdb |
Descriptor | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | phosphodiesterase, cgmp binding, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q9Y233 |
Total number of polymer chains | 2 |
Total formula weight | 80179.25 |
Authors | Amano, Y. (deposition date: 2013-09-04, release date: 2013-12-11, Last modification date: 2024-05-29) |
Primary citation | Hamaguchi, W.,Masuda, N.,Isomura, M.,Miyamoto, S.,Kikuchi, S.,Amano, Y.,Honbou, K.,Mihara, T.,Watanabe, T. Design and synthesis of novel benzimidazole derivatives as phosphodiesterase 10A inhibitors with reduced CYP1A2 inhibition. Bioorg.Med.Chem., 21:7612-7623, 2013 Cited by PubMed: 24238902DOI: 10.1016/j.bmc.2013.10.035 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.26 Å) |
Structure validation
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