Crystal structure of ERp46 Trx2 in a complex with Prx4 C-term

Summary for 3WGX

DescriptorThioredoxin domain-containing protein 5, Peroxiredoxin-4, GLYCEROL, ... (4 entities in total)
Functional Keywordspdi family member, thioredoxin domain, protein disulfide isomerase, isomerase
Biological sourceHomo sapiens (human)
Cellular locationEndoplasmic reticulum lumen (By similarity) Q8NBS9
Cytoplasm (By similarity) O08807
Total number of polymer chains4
Total molecular weight30227.96
Inaba, K.,Suzuki, M.,Kojima, R. (deposition date: 2013-08-13, release date: 2014-06-25)
Primary citation
Kojima, R.,Okumura, M.,Masui, S.,Kanemura, S.,Inoue, M.,Saiki, M.,Yamaguchi, H.,Hikima, T.,Suzuki, M.,Akiyama, S.,Inaba, K.
Radically different thioredoxin domain arrangement of ERp46, an efficient disulfide bond introducer of the mammalian PDI family
Structure, 22:431-443, 2014
PubMed: 24462249 (PDB entries with the same primary citation)
DOI: 10.1016/j.str.2013.12.013
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.1583000.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution