3WF7

Crystal structure of S6K1 kinase domain in complex with a purine derivative 1-(9H-purin-6-yl)-N-[3-(trifluoromethyl)phenyl]piperidine-4-carboxamide

3WF7 の概要

• エントリーDOI: 10.2210/pdb3wf7/pdb
• 関連するPDBエントリー: 3WE4 3WF5 3WF6 3WF8 3WF9
• 分子名称: Ribosomal protein S6 kinase beta-1, ZINC ION, 1-(9H-purin-6-yl)-N-[3-(trifluoromethyl)phenyl]piperidine-4-carboxamide, ... (5 entities in total)
• 機能のキーワード: serine/threonine protein kinase domain, transferase, phosphorylation, atp-binding, zinc-binding, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell junction, synapse, synaptosome . Isoform Alpha I: Nucleus. Isoform Alpha II: Cytoplasm: P23443
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37726.68

構造登録者

Niwa, H.,Shirouzu, M.,Yokoyama, S. (登録日: 2013-07-17, 公開日: 2014-08-06, 最終更新日: 2014-10-29)

• 主引用文献: Niwa, H.,Mikuni, J.,Sasaki, S.,Tomabechi, Y.,Honda, K.,Ikeda, M.,Ohsawa, N.,Wakiyama, M.,Handa, N.,Shirouzu, M.,Honma, T.,Tanaka, A.,Yokoyama, S.; Crystal structures of the S6K1 kinase domain in complexes with inhibitors; J.Struct.Funct.Genom., 15:153-164, 2014; PubMed: 25078151; DOI: 10.1007/s10969-014-9188-8

実験手法

X-RAY DIFFRACTION (1.85 Å)